FIG. 3.

Structural similarity between BAT3 domains and domains of other proteins, as determined by NCBI conservative domain homology analysis. The numbers on top denote the amino acid residues of the BAT3 peptide. The location of the BAT3 dominant negative peptide (BATdn) is shown as a box at the top of the BAT3 full-length protein. UBQ represents the ubiquitin-like peptide on BAT3; the region on the BAT3 peptide that is responsible for apoptotic activity contains a DEAD box, indicated as apoptosis. CAP and BAG1 indicate regions of homology to the adenylyl cyclase protein domain and BAG1 peptide, respectively. The box labeled ppro denotes the polyproline regions of BAT3, and the nuclear localization signal (37) is shown in the box labeled N.