TABLE 1.
Antiviral activity of CV-N against a variety of retroviral strains in cell culture
| Viral strain(s) | Cell culture type | EC50 (μM) |
|---|---|---|
| HIV-1 | ||
| HE | CEM | 0.005 |
| IIIB | CEM | 0.002 |
| NL4.3 | CEM | 0.0007 |
| PBMC | 0.014 | |
| BaL | M/Mb | 0.16 |
| HIV-2 | ||
| ROD | CEM | 0.002 |
| BV-5061W | PBMC | 0.033 |
| SIV Mac251 | MT-4 | 0.017 |
| PBMC | 0.16 | |
| HIV-1 clade isolatesa (A, B, C, D, A/E, F, G, O) | PBMC | 0.013-0.16 |
a
The representative members of each HIV-1 clade and their X4 and/or R5 tropism have been indicated in Materials and Methods.
b
M/M, monocyte/macrophage.