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MVA induces earlier downregulation of Bcl-2 and Bcl-XL expression in DCs than VV. Immature DCs were mock treated (shaded histogram), infected with rVV-EGFP (dotted histogram) or rMVA-GFP (dashed histogram) at an MOI of 10, or treated with LPS (1 μg/ml, solid histogram), and the intracellular levels of Bcl-2 and Bcl-XL were measured by using MAb staining and flow cytometry at 11, 22, and 48 h postinfection. These data are representative of results from three independent experiments.
