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. 2006 Sep;80(17):8745–8762. doi: 10.1128/JVI.00956-06

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Copyright © 2006, American Society for Microbiology

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FIG. 4. — Mapping the epitopes of anti-SF162 neutralizing antibodies. (A) Peptide-mediated interference of SF162 neutralization by sera from the ΔV2ΔV3gp140-immunized macaque CN63. Neutralization was performed in the absence (filled symbols and solid lines) and presence (open symbols and dashed lines) of V1 (squares) or V3 (circles) peptides. The percent reduction in neutralization at the IC₇₀ is indicated. (B) Peptide-mediated interference of SF162 neutralization by sera from the SHIV_SF162P4-infected macaque C640. The symbols are the same as in panel A. (C) Neutralization of SF162 and Δ2F5.4E10 by MAbs. IgG1b12, squares; 2F5, circles; 4E10, triangles; SF162, filled symbols; and Δ2F5.4E10, open symbols. (D) Neutralization of SF162 and Δ2F5.4E10 by pooled sera from the immunized animals and from the SHIV_SF162P4-infected animal. The IC₇₀ is shown for each serum pool on SF162 (black bars), and neutralization at the IC₇₀ for SF162 is shown for each serum pool on Δ2F5.4E10 (white bars).