TABLE 2.
Transmission of CWD prions to Tg mice expressing cervid PrP
| Transgenic line | Cervid PrP expression (n-fold) | Inoculum | Incubation time ± SEM (days) | No. of animals ill/no. of animals inoculated |
|---|---|---|---|---|
| Tg(ElkPrP)12577 | 2 | Elk1 | 184 ± 5.7 | 7/7 |
| MD1 | 200 ± 4.3 | 6/6 | ||
| MD3 | 200 ± 9.1 | 8/8 | ||
| WTD1 | 179 ± 9.1 | 7/7 | ||
| WTD2 | 182 ± 7.0 | 8/8 | ||
| Tg(ElkPrP)12580 | 2 | Elk1 | 204 ± 8.5 | 8/8 |
| Tg(ElkPrP)3934 | 1.5a | Elk1 | 264 ± 15.8 | 8/8 |
| Tg(ElkPrP+/+)3934 | 3 | Elk1 | 145 ± 9.0 | 7/7 |
| Tg(ElkPrP)12584 | 3 | Elk1 | 149 ± 8.3 | 7/7 |
| Tg(DePrP)10945 | 1 | Elk1 | 329 ± 22.2 | 8/8 |
| MD1 | 339 ± 25.9 | 8/8 | ||
| MD3 | 292 ± 17.6 | 8/8 | ||
| WTD1 | 408 ± 30.8 | 6/6 | ||
| WTD2 | 399 ± 21.6 | 5/5 | ||
| Tg(DePrP)10969 | 1 | Elk1 | 304 ± 21.0 | 6/7 |
| MD1 | 323 ± 16.1 | 8/8 |
a
Half of the level of ElkPrP expression in Tg(ElkPrP+/+)3934 mice.