TABLE 5.
Known host genes whose expression is changed the hippocampus of LCMV-cgPi mice exposed to an avoidance-learning testa
| Genbank accession no. | Mock signalb | LCMV-cgPi signalb | Signal ratio | P | Gene identityc |
|---|---|---|---|---|---|
| M27134 | 20.7 | 225.1 | 10.87 | 0.000006 | MHCIb K region locus 2 |
| U43086 | 43.6 | 462.9 | 10.62 | 0.000001 | GARG-49 |
| M58156 | 23.3 | 236.8 | 10.16 | 0.000004 | MHCI H-2K-f |
| AW047653 | 21.7 | 190.8 | 8.79 | 0.000333 | UBP43 |
| U06924 | 32.7 | 258.7 | 7.91 | 0.000001 | STAT1 |
| U43084 | 40.5 | 318 | 7.85 | 0.000001 | GARG-16 |
| M18237 | 65 | 505.9 | 7.78 | 0.000001 | Ig kappa chain V-region |
| AB035174 | 47.7 | 341.9 | 7.17 | 0.001304 | GalNAc alpha 2,6-sialyltransferase |
| AF099973 | 31.3 | 191 | 6.10 | 0.000285 | Schlafen2 |
| AJ007971 | 24.4 | 147.4 | 6.04 | 0.000001 | IIGP |
| X56602 | 54 | 310.4 | 5.75 | 0.000002 | ISG15 |
| X67809 | 177.7 | 1001.7 | 5.64 | 0.000001 | Peptidylprolyl isomerase C-associated protein |
| X16202 | 215.8 | 976.7 | 4.53 | 0.000001 | MHCI Q4 |
| M69069 | 351.3 | 1271 | 3.62 | 0.000002 | MHCI D region locus 1 |
| X01838 | 827.7 | 2918.6 | 3.53 | 0.000001 | Beta-2 microglobulin |
| V00746 | 490.5 | 1603.2 | 3.27 | 0.000001 | MHCI H-2K |
| U43085 | 24.8 | 78.1 | 3.15 | 0.000007 | GARG-39 |
| U51992 | 157.5 | 494.2 | 3.14 | 0.000001 | IRF9 |
| U60020 | 58.3 | 175.7 | 3.01 | 0.000004 | Transporter 1, ABC |
| AJ007972 | 86.7 | 204.6 | 2.36 | 0.001767 | GTPI |
| U19119 | 72.7 | 162.6 | 2.24 | 0.000021 | LRG-47 |
| U66918 | 113.1 | 25.3 | −4.47 | 0.00021 | Short stature homeobox 2 |
| AF035684 | 238.5 | 27.3 | −8.74 | 0.00002 | Mus musculus beta chemokine TCA4 |
Known host genes whose expression is changed in the hippocampus of LCMV-cgPi mice exposed to an avoidance-learning test. Groups of 10 LCMV-cgPi mice with virus titers of 104 to 105 PFU/ml and 10 age- and sex-matched uninfected controls were subjected to the Y-maze discriminated avoidance task as described for Fig. 3. After the last session on day 6, animals were immediately euthanized and hippocampus tissue was dissected. Hippocampus tissue was pooled, and total RNAs were isolated and used for gene profiling studies with Affymetrix murine genomic DNA array U74Av2. Genes were identified as described for Table 3. Displayed are the known host genes that showed consistent regulation differences of >3-fold between LCMV-cgPi mice and controls. The mean fluorescence intensities for each probe set and the signal ratios with corresponding P values of changes are indicated.
Fluorescence units (intensity).
MHCI, major histocompatibility complex class I.