FIG. 2.

Poxvirus T2-like molecules contain a conserved PLAD. Sequence similarity analysis of the N-terminal region of the myxoma virus (MV), Shope fibroma virus (SFV), VV strain Lister and Copenhagen, camelpox virus (CMLV), variola major virus strain Bangladesh (VAR bsh major), variola minor virus strain Garcia (VAR gar minor), monkeypox virus (MPV), and ectromelia virus (EV) T2 ORFs and human TNFR1 and TNFR2 reveals a highly conserved PLAD that overlaps the first CRD. Identical amino acids (bold) and conserved amino acid differences (gray) are indicated.