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IFG increases the lysosomal pool of N370S GlcCerase. (A) Wild-type and N370S fibroblast cultures were treated with or without 100 μM IFG for 5 days followed by fractionation of homogenized lysates on Percoll gradients. Fractions were collected, and β-N-acetylhexosaminidase activity was measured. The percent of total activity in each fraction is plotted. (B) Fractions were combined into three pools and subjected to SDS/PAGE and Western blot analysis. GCase, GlcCerase.
