Table 1.

Effect of IFG on GlcCerase activity

Cell type	[IFG], μM	Treatment time, days	Fold enhancement over untreated cells∗
N370S	10	5	2.4 ± 0.2
	30	3	2.4 ± 0.2
		5	3.0 ± 0.6
	100	3	2.2 ± 0.1
		5	2.6 ± 0.2
Wild type	30	5	1.3 ± 0.3

GlcCerase activity was measured in fibroblast lysates after treatment with IFG for 3 or 5 days. The GlcCerase activity of untreated N370S fibroblasts was 2.8 ± 0.5% of that measured in wild-type fibroblasts. Data shown are the mean ± SD of at least three experiments.

∗, P < 0.01 for all values.