Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IFG inhibits wild-type and N370S GlcCerase at neutral and acidic pH
| pH | IC50, nM |
|
|---|---|---|
| Wild type | N370S | |
| 5.2 | 30 | 128 |
| 6.4 | 9 | 26 |
| 7.2 | 5 | 18 |
GlcCerase activity was measured in wild-type and N370S fibroblast lysates in the presence of various concentrations of IFG. IC50 values, determined by plotting the percent inhibition of GlcCerase activity vs. log [IFG], represent the mean of two independent experiments. Standard errors were less than 5% for all IC50 values shown.
