Table 3.
Double-stranded vector genome copy numbers in nonhepatic tissuesa
Dose (× 1010) | Serotype | Brain | Lung | Spleen | Kidney | Intestine | Testis |
---|---|---|---|---|---|---|---|
180 | 8 | 1.1 ± 0.2b | 1.6 ± 0.2 | 1.4 ± 0.1 | 2.5 ± 0.4 | 1.5c | 1.4 ± 0.1 |
180 | 9 | 2.9 ± 0.3 | 4.6 ± 0.1 | 2.2 ± 0.1 | 3.1 ± 0.5 | 2.8 ± 0.2 | 3.2 ± 0.6 |
30 | 8 | 0.2 ± 0.0 | 0.3 ± 0.0 | 0.2 ± 0.0 | 0.4 ± 0.1 | 0.2 ± 0.0 | 0.2 ± 0.0 |
30 | 9 | 0.4 ± 0.1 | 0.7 ± 0.1 | 0.5 ± 0.0 | 0.6 ± 0.1 | 0.4 ± 0.0 | 0.5 ± 0.0 |
Double-stranded vector genome copy numbers were determined by Southern blot analysis (n = 2 each) and are expressed as double-stranded vector genomes per diploid genomic equivalent. Vector copy numbers in nonhepatic tissues not listed are summarized in Table 2B.
Mean ± |each value-mean value|.
Only one sample was available.