TABLE 3.
Performance characteristics of ParaSight F+V prototypes for detection of P. falciparuma
| Performance parameter | FV98
|
FV99-1
|
FV99-2
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of specimens | % of specimens (CI95)
|
No. of specimens | % of specimens (CI95)
|
No. of specimens | % of specimens (CI95)
|
|||||||
| Peru | Thailand | Overall | Peru | Thailand | Overall | Peru | Thailand | Overall | ||||
| Sensitivity | ||||||||||||
| Any level of parasitemia >0/μl | 542 | 95 (89-98) | 99 (98-100) | 98 (97-100) | 49 | 92 (75-100) | 94 (89-98) | 94 (89-97) | 164 | 95 (82-100) | 98 (94-100) | 98 (94-100) |
| >0-500/μl | 79 | 100 (74-100) | 97 (90-100) | 97 (91-100) | 33 | 83 (36-100) | 74 (54-89) | 76 (58-89) | 24 | 67 (22-96) | 89 (65-99) | 83 (63-95) |
| 501-1,000/μl | 31 | 80 (44-97) | 100 (84-100) | 94 (79-100) | 10 | 100 (3-100) | 100 (66-100) | 100 (69-100) | 8 | 100 (3-100) | 100 (59-100) | 100 (63-100) |
| 1,001-5,000/μl | 102 | 100 (86-100) | 99 (93-100) | 99 (95-100) | 22 | 100 (40-100) | 100 (81-100) | 100 (85-100) | 32 | 100 (74-100) | 100 (83-100) | 100 (89-100) |
| >5,000/μl | 330 | 94 (86-98) | 100 (99-100) | 99 (97-100) | 84 | 93 (68-100) | 100 (95-100) | 99 (94-99) | 100 | 100 (81-100) | 100 (96-100) | 100 (96-100) |
| Specificity | 2,349 | 35 (31-38) | 17 (15-19) | 22 (20-24) | 86 | 83 (79-87) | 83 (80-86) | 83 (80-86) | 694 | 97 (95-99) | 89 (85-92) | 93 (91-95) |
a
Mixed infections (P. falciparum and P. vivax) detected by microscopy were excluded from calculations of device performance (1998, n = 31; 1999, n = 19).