TABLE 5.
Performance characteristics of ParaSight F+V prototypes for detection of P. vivaxa
| Performance parameter | FV98 %
|
FV99-1 %
|
FV99-2 %
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of specimens | % of specimens (CI95)
|
No. of specimens | % of specimens (CI95)
|
No. of specimens | % of specimens (CI95)
|
|||||||
| Peru | Thailand | Overall | Peru | Thailand | Overall | Peru | Thailand | Overall | ||||
| Sensitivity | ||||||||||||
| Any level of parasitemia >0/μl | 649 | 93 (88-96) | 93 (90-95) | 93 (90-94) | 249 | 97 (91-100) | 86 (79-91) | 90 (86-94) | 234 | 85 (78-91) | 88 (81-94) | 87 (82-91) |
| >0-500/μl | 152 | 67 (43-85) | 82 (74-88) | 80 (72-86) | 59 | 83 (52-98) | 62 (46-75) | 66 (53-78) | 53 | 46 (27-67) | 63 (42-81) | 55 (40-68) |
| 501-1,000/μl | 44 | 87 (60-98) | 83 (64-94) | 84 (70-93) | 19 | 88 (47-100) | 100 (72-100) | 95 (74-100) | 16 | 88 (47-100) | 100 (63-100) | 94 (70-100) |
| 1,001-5,000/μl | 181 | 92 (82-97) | 98 (93-100) | 96 (91-98) | 67 | 100 (89-100) | 92 (78-98) | 96 (87-100) | 64 | 92 (78-98) | 93 (76-100) | 92 (83-97) |
| >5,000/μl | 272 | 99 (95-100) | 99 (97-100) | 99 (97-100) | 104 | 100 (93-100) | 100 (94-100) | 100 (97-100) | 101 | 100 (93-100) | 98 (89-100) | 99 (95-100) |
| Specificity | 2,242 | 39 (35-43) | 21 (19-23) | 26 (24-27) | 76 | 44 (37-50) | 72 (67-75) | 62 (59-66) | 623 | 94 (90-96) | 82 (77-86) | 87 (84-89) |
a
Mixed infections (P. falciparum and P. vivax) detected by microscopy were excluded from calculations of device performance (1998, n = 31; 1999; n = 19).