FIG. 1.

IS6110 RFLP and spoligotype patterns of 40 M. tuberculosis isolates originating from the Philippines. Shown is a combined dendrogram based on the similarities of the patterns on the basis of both typing methods. Strains 5 to 39 represent the Manila family, described in this study. Note that the spoligotype patterns of these strains are all identical, except those of strains 5 and 27, which lack one spacer. Strain 40 exhibits fingerprints characteristic of the Beijing genotype of M. tuberculosis. Numbers at the bottom indicate the sizes of the PvuII restriction fragments in kilobase pairs (left) and the spacer oligonucleotides (right).