TABLE 1.
SNPs in HHV-8 ORF26 amplified from PBMC DNA
| Patient | SNP at the following nucleotide position in ORF26a:
|
ORF K1 subtypeb | KSc | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 935 | 981 | 1032 | 1055 | 1086 | 1094 | 1103 | 1122 | 1132 | 1139 | |||
| BCBL-R | C | T | C | G | C | G | C | G | A | A | A1 | |
| 1 | — | — | A | T | — | — | — | — | — | — | NP | + |
| 2 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 3 | — | — | — | — | — | — | — | — | — | — | A4 | + |
| 4 | — | C | A | T | — | — | — | — | G | C | A5 | + |
| 5 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 6 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 7 | — | — | — | — | — | — | — | — | — | — | NP | + |
| 8 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 9 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 10 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 11 | — | — | — | — | — | — | — | — | — | — | A1 | + |
| 12 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 13 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 14 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 15 | — | — | — | — | — | — | — | — | — | — | A1′d | + |
| 16 | — | C | A | T | — | — | — | — | G | C | A4′d | + |
| 17 | A | C | — | — | T | — | — | — | — | C | C3′d | + |
| 18 | — | — | — | — | — | — | A | — | — | — | NP | + |
| 19 | — | — | — | — | — | — | A | — | — | — | + | |
| 20 | — | C | A | T | — | — | — | — | G | C | + | |
| 21 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 22 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 23 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 24 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 25 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 26 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 27 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 28 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 29 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 30 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 31 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 32 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 33 | — | — | — | — | — | — | A | — | — | — | NP | − |
| 34 | — | — | — | — | — | — | — | — | — | — | − | |
| 35 | — | — | — | — | — | — | — | — | — | — | − | |
| 36 | — | — | — | — | — | — | A | — | — | — | − | |
| 37 | — | — | — | — | — | — | — | — | — | — | − | |
| 38 | — | C | — | — | T | — | — | — | — | C | − | |
| 39 | — | — | — | — | — | — | A | — | — | — | − | |
| 40 | — | — | — | — | — | — | A | — | — | — | − | |
| 41 | — | — | — | — | — | — | — | — | — | — | − | |
| 42 | — | — | — | — | — | — | A | — | — | — | − | |
| 43 | — | — | — | — | — | — | A | — | — | — | − | |
| 44 | — | — | — | — | — | — | A | — | — | — | − | |
| 45 | — | — | — | — | — | — | A | — | — | — | − | |
| 46 | — | C | — | — | — | — | — | — | G | C | − | |
| 47 | — | — | — | — | — | — | A | — | — | — | − | |
| 48 | — | — | — | — | — | — | — | — | — | — | − | |
| 49 | — | — | — | — | — | — | A | — | — | — | − | |
| 50 | — | — | — | — | — | — | — | — | — | — | − | |
| 51 | — | — | — | — | — | — | A | — | — | — | − | |
| 52 | — | — | — | — | — | — | — | — | — | — | − | |
| 53 | — | C | — | — | — | — | — | — | — | C | − | |
| 54 | — | C | — | — | — | — | — | — | — | C | − | |
| 55 | — | — | — | — | — | — | — | — | — | — | − | |
| 56 | — | — | — | — | — | — | A | — | — | — | − | |
| 57 | — | — | — | — | — | — | A | — | — | — | − | |
| 58 | — | — | — | — | — | — | — | — | — | — | − | |
| 59 | — | — | — | — | — | — | A | — | — | — | − | |
a
Nucleotide positions of ORF26 SNPs reported by Poole et al. (16). Nucleotides in the first entry represent HHV-8 sequences derived from the BCBL-R cell line. —, no polymorphism.
b
ORF-K1 subtypes determined by phylogenetic analysis of ORF K1 sequences. NP, no PCR fragments were obtained by PCR of PBMC DNA.
c
Past or present history of KS. +, present; −, absent.
d
Data were obtained from KS tissue DNA. ORF K1 fragments could not be obtained from PBMC DNA for these patients.