TABLE 2.
Eight SNPs types of ORF26 sequences obtained from 59 HHV-8-infected patients
| SNP type | SNP at the following nucleotide position (BCBL-R cell line nucleotide) in ORF26a:
|
Corresponding ORF K1 subtypesb | No. (%) of patientsc
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 935(C) | 981(T) | 1032(C) | 1055(G) | 1086(C) | 1103(C) | 1132(A) | 1139(A) | Total | With KS | ||
| 1 | — | — | — | — | — | A | — | — | A3 | 37 (62.7) | 11 (29.7) |
| 2 | — | — | — | — | — | — | — | — | A1, A1′, A2, A4, C2, C3d | 13 (22.0) | 4 (30.8) |
| 3 | — | C | A | T | — | — | G | C | C3 | 3 (5.1) | 3 (100) |
| 4 | — | C | — | — | — | — | — | C | ND | 2 (3.4) | 0 (0) |
| 5 | A | C | — | — | T | — | — | C | C3′ | 1 (1.7) | 1 (100) |
| 6 | — | C | — | — | T | — | — | C | A5, B, C1, C2, C4, C5d | 1 (1.7) | 0 (0) |
| 7 | — | C | — | — | — | — | G | C | B | 1 (1.7) | 0 (0) |
| 8 | — | — | A | T | — | — | — | — | ND | 1 (1.7) | 1 (100) |
a
Nucleotides at positions 1094 and 1122 are not included because no SNPs were found at these positions in 59 samples. The nucleotides in bold type amino acid substitutions (T981C: Phe→Leu; C1032A: Leu→Ile; A1132G: Asp→Gly).
b
Based on the molecular data reported by Poole et al. (16). ND, no corresponding ORF26 SNPs.
c
Percentages represents the relative proportions of patients with each SNP type out of 59 patients (total) or the proportions of patients with each SNP out of patients with a past or present, history of KS.
d
ORF26 SNPs cannot distinguish these subtypes.