TABLE 4.

pbp5 allele polymorphism and ampicillin susceptibility of 102 isolates of E. faecium^a

Allele	No. of isolates	Amino acid at position:																	MIC range of ampicillin (mg/liter)	No. of isolates
		461	466′	470	485	496	497	499	524	525	558	582	586	593	607	629	631	634		S	R
		Q	—	H	M	N	F	A	E	E	A	G	V	L	L	E	G	N
1	50	Q	—	Q	T	K	F	T	E	D	A	G	L	L	L	V	G	N	6-128	4	46
2	23	Q	D	Q	T	K	F	T	E	D	A	G	L	L	L	V	G	N	16->256	0	23
3	14	Q	—	Q	M	N	F	A	E	E	A	G	V	L	L	E	G	N	0.064-96	12	2
4	4	Q	—	Q	M	K	F	T	E	D	A	G	V	L	L	V	G	N	1.5-32	2	2
5	2	Q	D	Q	T	K	L	T	E	D	A	S	V	Q	L	V	G	N	64-256		2
6	2	Q	—	Q	A	K	F	T	E	D	A	G	L	L	L	V	G	N	48-64		2
7	2	Q	—	Q	M	N	F	A	G	E	A	G	V	L	L	E	R	N	1-48	1	1
8	1	Q	S	Q	T	K	F	T	E	D	V	G	V	L	L	V	G	N	256		1
9	1	K	—	Q	A	K	F	T	E	D	A	G	L	L	L	V	G	T	96		1
10	1	Q	—	Q	T	K	F	T	E	D	A	G	V	L	F	V	G	N	64		1
11	1	Q	—	Q	M	K	F	I	E	D	A	G	V	L	L	E	G	N	0.25	1
12	1	Q	—	Q	M	K	F	T	E	D	A	G	V	L	L	E	G	N	0.125	1

^aAmino acid positions are based on the sequence of pbp5 (GenBank and EMBL accession no. X84860). DNA corresponding to amino acids 447 to 635 was sequenced.