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Effect of IL-4 (2.5–10 ng, 100 μl, i.pl.) on hyperalgesic response to injections (in 100 μl, i.pl.) of carrageenin (Cg, 100 μg), bradykinin (BK, 500 ng), TNFα (2.5 pg), IL-1β (0.5 pg), IL-8 (100 pg), and PGE2, (100 ng). IL-4 was injected into paws to be injected with a hyperalgesic agent, 30 min before the hyperalgesic agent. The intensity of hyperalgesia was measured 3 h after injection of hyperalgesic agents. Means±s.e.means in groups of five rats are shown.
