Figure 5.

Effect of a MAb to IL-4, BVDG (50 μg in 50 μl, i.pl., horizontally hatched columns) and a control MAb (open columns) on hyperalgesic responses to injections (in 100 μl, i.pl.) of bradykinin (BK, 50 ng, panel A,B) and dextran (200 μg, panel C) in athymic (nude) rats (panel A), wild type rats (panel C) and wild type rats depleted of mast cells (panel B). The MAbs were injected into paws to be injected with a hyperalgesic agent, 30 min before the hyperalgesic agent. The intensity of hyperalgesia was measured 3 h after injection of hyperalgesic agents. Means±s.e.means in groups of five rats are shown; ^**P<0.0001.