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. 1999 Jan;126(1):51–60. doi: 10.1038/sj.bjp.0702267

Figure 2.

Figure 2

Effects of rotenone and oligomycin on membrane potential and whole cell currents. (a) The upper panel is a current clamp record of a cell dialysed with a 5 mM ATP-containing electrode solution. Application of rotenone (10 μM) for the time indicated had no effect on the resting membrane potential of CRI-G1 cells. (b) Current-voltage relations for the voltage clamped macroscopic currents at the times specified in a: control (▵) and 10 μM rotenone (•). Rotenone had no effect on the membrane conductance of CRI-G1 insulinoma cells. (c) Current clamp record of a CRI-G1 cell dialysed with a 5 mM ATP-containing electrode solution. Addition of oligomycin (2 μM) for the time indicated had no effect on the resting membrane potential of the cell. (d) Plot of the current-voltage relations for the voltage clamped currents obtained in c; control (▵) and oligomycin (•). Oligomycin failed to affect the slope conductance of CRI-G1 cells.