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Effect of (RS)-PeCPG on L-glutamate-evoked Ca2+ release in CHO cells expressing the mGlu5a receptor. Representative experiment demonstrating the method for determining the KB value for a single phenylglycine derivative. Increasing concentrations of L-glutamate used to evoke a Ca2+ release in the absence and presence of 1 mM (RS)-PeCPG. EC50 values derived using non-linear least squares analysis were 5±2 and 21±11 μM, respectively giving a KB value of 312 μM.
