Figure 5.

Effects of nefiracetam on step-through latency (A) and the number of training trials (B) in the multiple-trial passive avoidance task in the Aβ-(1-42)-treated rats. The task was carried out on days 17–18 after the start of Aβ infusion. Daily oral administration of nefiracetam was started on day 7, and the passive avoidance task was carried out 1 h after the administration. Values are the means±s.e.mean (n=8–9). ^**P<0.01 vs Aβ-(40-1)-treated control rats. ##P<0.01, ###P<0.001 vs Aβ-(1-42)-treated rats.