Figure 6.
Peroxynitrite formation (A) and DNA single strand breakage development in pleural macrophages harvested from control and carrageenan-treated rats. Four hours after carrageenan injection a significant peroxynitrite production and a marked increase in DNA strand breakage was observed. Raxofelast significantly (5, 10, 20 mg kg−1) inhibited in a dose dependent manner dihydrorhodamine 123 oxidation and prevented the carrageenan-induced DNA single strand breakage. Data represent the number of wells studied (6–9 wells from 2–3 independent experiments). *P<0.01 versus macrophages from control rats; °P<0.01 represents a significant inhibitory effect of raxofelast.