Figure 7.
Reduction of mitochondrial respiration (A) and cellular levels of NAD+ (B) in macrophages from control and carrageenan-treated rats. Four hours after carregeenan administration the disruption of cellular energetic pool was evidenced by a significant decrease in mitochondrial respiration and intracellular concentration of NAD+. Raxofelast (5, 10, 20 mg kg−1) significantly inhibited in a dose dependent manner the decrease in cellular respiration and partially restored the depletion of intracellular levels of NAD+. Data represent the number of wells studied (6–9 wells from 2–3 independent experiments). *P<0.01 versus macrophages from control rats; °P<0.01 represents protective effects of raxofelast.