Figure 2.

Effects of clopidogrel (0.3–30 μM) on ADP (6 μM)-, collagen (2.5 μg ml⁻¹), U46619 (1 μM) or thrombin (0.1 u ml⁻¹)-induced aggregation of washed human platelets. The aggregation was assessed by measuring the maximum change of light transmission (A) and the change of light transmission 4 min after addition of the stimulus (B). Data are given as % of aggregation response induced by the respective agonists without clopidogrel (control=100%). (means±s.e.mean of n=5–6 independent experiments, ^*P<0.05 vs control, Student's t-test for paired data).