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Typical traces representing thrombin- and TRAP-9-induced bronchoconstriction (a and c) and changes in arterial blood pressure (b and d). Thrombin (100 u kg−1) and TRAP-9 (1 mg kg−1) were administered for three consecutive times each 20 min, bronchoconstriction and arterial blood pressure were evaluated. Histamine (10 μg kg−1 i.v.) was previously administered to check animal responsiveness to a bronchoconstrictory agent.
