Figure 2.
Effects of HOE140 on the development of deoxycorticosterone acetate-salt hypertension in rats under ebelactone B treatment. Values are means±s.e.mean obtained. After uninephrectomy at 6 weeks of age, deoxycorticosterone acetate (5 mg kg−1, s.c.) was administered once a week. Ebelactone B (5 mg kg−1) was administered orally twice a day from the first day of deoxycorticosterone acetate-salt treatment. HOE140 was continuously infused subcutaneously using a micro-osmotic pump (5 mg kg−1 day−1, dissolved in physiological saline). ANOVA was used to evaluate the significance of differences.