Figure 6.

Concentration-recovery curves (means±s.e.mean) for bolus injections (10 μl) of N-substituted S-nitrosothiols into the perfusate of (a) endothelium-intact vessels, (b) endothelium denuded vessels and (c) endothelium-denuded vessels perfused with 10 μM Hb (n=8 for all compounds under each condition). Significant differences in (b) are as shown (^*P<0.05, ^**P<0.01, ^***P<0.001). Responses to the four analogues were not significantly different from each other in (a) and (c; P>0.05; repeated dose, 2 factor ANOVAs).