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Concentration-response curve for the influence of noc/OFQ on the beating rate of spontaneously beating cardiomyocytes in cultured neonatal rat heart cells in absence and presence of the hexapeptide Ac-RYYRIK-NH2 (a) and kinetics of the inhibiting effect of 10 μM hexapeptide Ac-RYYRIK-NH2 on the beating rate induced by 10 μM noc/OFQ before (b). The basal beating rate was 150±4.5 beats min−1; n=20–38.
