Figure 3.

Effect of pinacidil on different doses of clonidine and guanabenz in the mouse hot-plate test. (a) Enhancement by pinacidil (25 μg per mouse, i.c.v.) of clonidine (0.05–0.20 mg kg⁻¹, s.c.) antinociception. Vertical lines represent s.e.mean; between 14 and 16 mice were tested. ^*P<0.05 in comparison with clonidine-treated mice. (b) Enhancement by pinacidil (25 μg per mouse, i.c.v.) of guanabenz (0.05–0.30 mg kg⁻¹, s.c.) antinociception. Vertical lines represent s.e.mean; between 15 and 18 mice were tested. ^*P<0.05 in comparison with guanabenz-treated mice.