Figure 5.

Simvastatin and simvastatin-acid, but not pravastatin, inhibit glucose-induced insulin secretion in islets. Insulin release from islets stimulated with 8.3 mM glucose, under static incubation conditions, was inhibited in the presence of 0.3 μg ml⁻¹ simvastatin (Simva). Glucose-stimulated insulin release was mildly reduced by 30 μg ml⁻¹ simvastatin-acid (Simva-a), but not significantly. Pravastatin (Prava) at 100 μg ml⁻¹ was without effect on glucose-stimulated insulin release. The results are expressed as the mean±s.e.mean of six experiments. #, Significant difference (P<0.05) vs the 8.3 mM glucose (G8.3) group and the pravastatin group.