Figure 6.

Simvastatin inhibits Ca²⁺ currents in single β-cells. (A) Whole-cell Ca²⁺ currents in a single β-cell depolarized to 0 mV from the holding potential of −70 mV before (a), during (b) and after exposure to 3 μg ml⁻¹ simvastatin (c) under superfusion conditions. (B) Recording of the temporal change of the whole-cell Ca²⁺ currents. a, b and c, specify the time points at which the current traces in Aa, Ab and Ac were taken. (C) The current-voltage relationship of the peak Ca²⁺ current amplitude in the control and in the presence of 3 μg ml⁻¹ simvastatin. The results shown are representative of five cells in (A) and (B) and three in (C).