Figure 3.

Effect of PKA inhibitors on the βAPP maturation by Swedish mutated βAPP-expressing HEK293 cells. Stably transfected HEK293 cells overexpressing Swedish mutated βAPP were incubated as in Figure 2 and analysed for βAPP (A), Aβ40 and x-40 (B), Aβ42 and x-42 (C), APPα (D) and p10 (E) as described in the Figure 2. Densitometric analyses of Aβ40 and Aβ42 recoveries were quantified as in the Figure 2 and are the means±s.e.mean of 4–5 independent experiments.