Figure 2.

Basal and capsaicin-evoked spinal PGE₂ levels after 5–72 h of knee joint inflammation. (A) PGE₂ levels from spinal cords of naive cohorts are presented at T=0. Note that basal PGE₂ levels increase from 5–72 h after injury and return to naive PGE₂ levels by 96 h post-injury. (B) Knee joint circumference after injection of kaolin/carrageenan to the knee joint capsule increases (ipsilateral) as compared to the un-injected knee (contralateral) with a similar time course to increases in spinal PGE₂ level. Each data point represents the mean±s.e.mean of 4–8 animals. Significant increases in basal PGE₂ release (A) and knee joint circumference (B) after inflammation are indicated by ^**P<0.01 as compared to naive cohorts. Significant capsaicin-evoked increases in PGE₂ at each time point after inflammation are indicated by ‡P<0.005.