Figure 3.

Terikalant dose-dependently increased action potential duration. (a) Intracellular action potentials measured at steady state, in control and two concentrations of terikalant, from an isolated ventricular myocyte at two different cycle lengths. The initial spikes in the action potentials are stimulus artifacts. (b) APD₉₀ increases with terikalant concentration and the drug is more effective at 300 ms than at 500 ms CL. Values for APD₉₀ have been normalized to the control value in the absence of terikalant, for each experiment. Action potentials were longer than the 300 ms cycle length at concentrations above 10 μM so that APD₉₀ could not be measured. The number of samples is given by the number above each point. ^***P<0.001 (one-tailed, paired t-test).