Figure 3.
Endomorphin-1 is a partial agonist in PAG neurons. (i) A time plot of the peak amplitude of IBa illustrating the effects of application of endomorphin-1, endomorphin-1 with met-enkephalin and subsequently met-enkephalin alone. IBa was elicited by repetitively stepping the membrane potential of the neuron from −90 mV to 0 mV. Note that the abscissa has been truncated so the effects of the agonists can be more easily compared. Endomorphin-1 occluded the effects of met-enkephalin by about 20% in nine cells tested. (ii) Selected traces from the same experiment, showing the IBa in each condition.