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. 1999 Apr;126(7):1681–1684. doi: 10.1038/sj.bjp.0702487

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Copyright 1999, Nature Publishing Group

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Artificially ventilated anaesthetized cats: traces showing the effects of topical application to the ‘glycine-sensitive area' of the ventrolateral medulla of DOI, 30 μg each side, from one experiment, and from another, NMDA, 10 μg each side. In each experiment the heart was electrically paced and the mean arterial blood pressure was maintained constant. Panels A and C, initial control states 1 min before the application of the drugs to the medulla; panels B and D, final control states after rinsing the medulla with sodium chloride solution, 154 mM. Panel DOI was taken 3 min after the application of the drug, panel B 5 min after rinsing the area with sodium chloride solution. Panel NMDA was taken 2 min after the application of the drug, panel D 8 min after rinsing the area with the sodium chloride solution (154 mM). Records from above downwards: P limb, hindlimb mean perfusion pressure; LV (left ventricular) dP/dt max; Ptr, tracheal pressure; P lv, e-d, left ventricular end-diastolic pressure; PI, pulse interval; Pa, , phasic and mean arterial blood pressure; RM, respiratory movements (inspiration upwards); P lv, left ventricular pressure. Time calibration, 1 s.

Inline graphic — Artificially ventilated anaesthetized cats: traces showing the effects of topical application to the ‘glycine-sensitive area' of the ventrolateral medulla of DOI, 30 μg each side, from one experiment, and from another, NMDA, 10 μg each side. In each experiment the heart was electrically paced and the mean arterial blood pressure was maintained constant. Panels A and C, initial control states 1 min before the application of the drugs to the medulla; panels B and D, final control states after rinsing the medulla with sodium chloride solution, 154 mM. Panel DOI was taken 3 min after the application of the drug, panel B 5 min after rinsing the area with sodium chloride solution. Panel NMDA was taken 2 min after the application of the drug, panel D 8 min after rinsing the area with the sodium chloride solution (154 mM). Records from above downwards: P limb, hindlimb mean perfusion pressure; LV (left ventricular) dP/dt max; Ptr, tracheal pressure; P lv, e-d, left ventricular end-diastolic pressure; PI, pulse interval; Pa, , phasic and mean arterial blood pressure; RM, respiratory movements (inspiration upwards); P lv, left ventricular pressure. Time calibration, 1 s.