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Effects of D890 on IK(DR). Families of current evoked by depolarizing pulses from −60 to +80 mV in 20 mV steps (VH=−70 mV) with pipette solution containing 100 μM D890. (A) Current traces recorded immediately after rupture of the patch membrane, when only a negligible fraction of the drug has diffused into the cell. (B) Currents recorded 10 min later, when steady-state of block had been reached. Bath solution, Na-Physiological Salt Solution (PSS).
