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Typical responses of individual 5-HT neurones to iontophoretic 8-OH-DPAT application with increasing currents before (a) and after (b) transection of the frontal cortex. Systemic administration of WAY 100635 (0.1 mg kg−1, i.v.; indicated by arrow) antagonized the inhibitory effect of iontophoretically applied 8-OH-DPAT (c; neurone recorded after transection). Bars represent the duration of drug application at the current (nA) indicated.
