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Effect of local, bilateral microinjection of 8-OH-DPAT (1 μg μl−1) into the mPFC (a) or CPu (b) on the activity of DRN 5-HT neurones. Horizontal bars indicate the duration of 8-OH-DPAT infusion. Systemic administration of WAY 100635 (0.1 mg kg−1, i.v.; indicated by arrows) reversed the inhibition of 5-HT neurones induced by either mPFC or CPu microinjection of 8-OH-DPAT.
