Figure 5.

Effect of oral administration of SB207499 on the trafficking of ¹¹¹In-eosinophils to skin sites injected with PAF, ZAP or in the PCA reaction. SB207499 was administered p.o. 1 h before i.v. injection of ¹¹¹In-eosinophils and i.d. injection of PAF (1 nmol), ZAP (30%) or antigen (1 μg BGG, shown as PCA). Accumulation of ¹¹¹In-eosinophils in sites was assessed after 1 h. Values are mean±s.e.mean of experiments in 4–6 animals at each dose and have been subtracted for saline values (233±58 ¹¹¹In-eosinophils per site).