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Competition experiments of specific [3H]-PZ and [3H]-KMD binding by various α1-AR antagonists in rat kidney. (a) 200 pM [3H]-PZ or (b) 100 pM [3H]-KMD was incubated with rat kidney membranes in the presence of unlabelled drugs. Competition curves of YM-617, KMD-3213 and WB4101 against [3H]-PZ binding were significantly fitted to two-site model (P<0.05), and other curves were fitted to one-site model. Data are shown as mean±s.e.mean of three independent experiments.
