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Antagonism of contractions to agonists by KMD-3213. (a) Concentration response curves to NS-49 in rat caudal artery are shown. •, Control; ▴, KMD-3213 0.03 nM; ⧫, 0.3 nM; ▪, 3 nM. (b) Concentration response curves to NA in dog carotid artery are shown. •, Control; ▴, KMD-3213 0.03 μM; ⧫, 0.3 μM; ▪, 3 μM. Data are shown as mean±s.e.mean of 5–6 independent experiments.
