Figure 1.

Dose-response relations for GABA-currents evoked by different types of GABA_A receptors expressed by rat cerebral cortex mRNA or human cloned α₁β₂ and α₁β₂γ_2S subunits. Responses were normalized and fitted with the Hill relation. Each point shows the mean±s.e.mean for 5–8 oocytes. Inset: Sample currents elicited in an oocyte injected with rat cortex mRNA. In this and subsequent traces the bars above the records indicate the times of drug applications to oocytes clamped at −60 mV; and inward currents are denoted by downward deflections of the traces.