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Pitrazepin does not interact with the benzodiazepine site of α1β2γ2S receptors. (A) Pitrazepin inhibits the current induced by GABA whereas flunitrazepam potentiates it. (B) Co-application of GABA plus flumazenil did not affect the inhibition by pitrazepin, but strongly antagonized the flunitrazepam potentiating effect.
