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TNF-α, but not neutral sphingomyelinase or IL-1β, induces chromatin condensation in LNCaP cells. Cells were incubated with each agent for 48 h, fixed in methanol/acetic acid, stained with bisbenzimide and visualized by fluorescence microscopy. A=control; B=neutral sphingomyelinase (200 mU ml−1); C=IL-1β (1 ng ml−1); D=TNF-α (20 ng ml−1). Arrowheads indicate condensed nuclei.
