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. 1999 May;127(1):177–187. doi: 10.1038/sj.bjp.0702530

Figure 2.

Figure 2

Figure 2

Effects of PK 11195, CB compounds and alprazolam on GABA-evoked Cl− currents in Xenopus oocytes expressing human recombinant α1β2γ2S GABAA receptors. (A) Tracings were obtained from a single oocyte expressing human α1β2γ2S GABAA receptors and show the effect of the different CB compounds on GABA-evoked Cl− currents. Drugs were perfused together with GABA at the concentration of 3 μM for 20 s. (B) Data represent the per cent change in the control response to GABA at the EC20 (2–10 μM) induced by various concentrations of each test drug, and are means±s.e.mean for 4–7 different oocytes. aP<0.05, bP<0.01 vs control.