Figure 5.

Effects of pretreatment with PK 11195 on the CB 34-induced increases in the cerebrocortical concentrations of neuroactive steroids. Rats were injected with PK 11195 (40 mg kg⁻¹, i.p.) 10 min before CB 34 (25 mg kg⁻¹, i.p.), and were killed 30 min after CB 34 administration. Data are means±s.e.mean of 8–10 rats and are expressed as a percentage of the corresponding concentrations for vehicle-treated rats. ^aP<0.05, ^bP<0.01 vs vehicle-treated animals. ^cP<0.01 vs CB 34-treated animals.