Figure 3.

Time course of the effect of paroxetine (0.8 mg kg⁻¹ i.v.) on 5-HT levels in dialysates of the frontal cortex in vehicle- and (−)- penbutolol- (2.4 mg kg⁻¹) pretreated animals. The vehicle was distilled water. Drugs were given as indicated by the arrows. Basal levels of 5-HT were 11±2 (5), 10±1 (5), 14±2 (6) and 9±1 (6) fmol sample⁻¹, in the groups of animals which received vehicle/vehicle, (−)-penbutolol/vehicle, vehicle/paroxetine and (−)-penbutolol/paroxetine, respectively. Data for the vehicle/vehicle treated group are taken from Figure 2.