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. 1999 May;127(1):145–152. doi: 10.1038/sj.bjp.0702546

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Copyright 1999, Nature Publishing Group

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Rate meter recordings showing the effect of (−)-tertatolol and WAY 100635 on the inhibitory response to paroxetine in individual 5-HT cells in the DRN. Drugs were given as indicated by the arrows. (a) Shows a cell in which (−)-tertatolol caused near complete reversal of the effect of paroxetine. (b) Shows a cell in which the reversal by (−)-tertatolol was partial whilst (c) shows a cell in which (−)-tertatolol was ineffective. Note that subsequent administration of WAY 100635 reversed the inhibitory effect of paroxetine in the cells shown in (b) and (c).

Rate meter recordings showing the effect of (−)-tertatolol and WAY 100635 on the inhibitory response to paroxetine in individual 5-HT cells in the DRN. Drugs were given as indicated by the arrows. (a) Shows a cell in which (−)-tertatolol caused near complete reversal of the effect of paroxetine. (b) Shows a cell in which the reversal by (−)-tertatolol was partial whilst (c) shows a cell in which (−)-tertatolol was ineffective. Note that subsequent administration of WAY 100635 reversed the inhibitory effect of paroxetine in the cells shown in (b) and (c).